A newly registered compound, pyroxasulfone or trade name Zidua was recently approved for use as an herbicide in potato production. Prior to this compound receiving a label for use we wanted to determine the effects of pyroxasulfone on cultivar tolerance and the effects of tank mixtures with pyroxasulfone on weed control. Studies were performed in 2017 and 2018 near Park Rapids, MN. Eight cultivars tested expressed no injury at 0, 128 or 256 g ae ha^-1. When adding 128 g ha^-1 pyroxasulfone with rimsulfuron, S-metolachlor, metribuzin, pendimethalin, or dimethenamid all treatments resulted in good weed control of common lambsquarters (Chenopodium album) and eastern black nightshade (Solanum ptycanthum) and favorable yield of Russet Burbank and Umatilla Russet potatoes.