Nematode pests of potato are among some of the most highly regulated plant pests in the world, due to their impact on trade, detrimental effect on yield, and ease by which they can be spread in infested tubers or soil. Productivity of the U.S. potato industry depends upon successfully implementing a systems approach to managing invasive nematode species such as potato cyst (PCN) or root knot nematodes (RKN). Many steps are involved in a systems approach to nematode control. Highly susceptible varieties, lack of rapid diagnostics, unreliable thresholds, and limited selection of nematicides are constraints to effective control of plant-parasitic nematodes for the potato industry. Currently, nematode control largely relies on nematicides, yet many are being phased out or are no longer available. Although use of resistance is one of the most sustainable and effective measures for plant pest control, commercially acceptable potato varieties resistant to RKN and PCN do not exist in the U.S, and a systems approach is, as yet, undeveloped. Our goal is to provide information, tools, and best management practices for the decision-making process for nematode control. Measures to improve diagnostic methods and decision support tools, efforts to develop potatoes resistant to the Columbia root knot nematode, Meloidogyne chitwoodi, pale cyst nematode, Globodera pallida, and to the golden nematode, Globodera rostochiensis pathotype Ro2; and continued development of novel nematicides from the trap crop Solanum sisymbriifolium will be discussed.