The time period after tuber initiation/induction and prior to vine kill is critical for the establishment and development of potato tubers. This talk will focus on these growth stages, primarily on tuber establishment and tuber bulking. A series of physiological and biochemical processes are involved with tuberization and tuber development in potato, including metabolic substances, transport and distribution of assimilates and hormone signaling. Foliar maturation occurs at the same time as nutrient allocation, as the plant progresses towards senescence, leading to changes in tuber formation. Time course measurements in leaves and stolons of sugars and carbohydrates provide a detailed picture of tuber growth and development. Numerous factors, including abiotic and genetic, contribute to and alter these processes. A more thorough understanding of these processes would enhance our ability to maximize tuber quality and yield.